Research

1.      Mehata AK, Bonlawar J, Tamang R, Malik AK, Setia A, Kumar S, Challa RR, Vallamkonda B, Koch B, Muthu MS. PLGA Nanoplatform for the Hypoxic Tumor Delivery: Folate Targeting, Therapy, and Ultrasound/Photoacoustic Imaging. ACS Appl. Bio Mater. 2024, 7, 8, 5754–5770

2.      Dhamija P†, Mehata AK†, Tamang R, Bonlawar J, Vaishali, Malik AK, Setia A, Kumar S, Challa RR, Koch B, Muthu MS. Redox-Sensitive Poly (lactic-co-glycolic acid) Nanoparticles of Palbociclib: Development, ultrasound/photoacoustic imaging, and smart breast cancer therapy. Molecular Pharmaceutics. 2024. († equally contributed).

3.      Mehata AK, Singh V, Vikas, Singh N, Mandal A, Dash D, Koch B, Muthu MS. Chitosan-g-estrone nanoparticles of palbociclib vanished hypoxic breast tumor after targeted delivery: development and ultrasound/photoacoustic imaging. ACS Applied Materials & Interfaces. 2023;15(29):34343-59.

4.      Mehata AK, Singh V, Srivastava P, Koch B, Kumar M, Muthu MS. Chitosan nanoplatform for the co-delivery of palbociclib and ultra-small magnesium nanoclusters: dual receptor targeting, therapy and imaging. Nanotheranostics. 2024;8(2):179-201.

5.      Mehata AK, Bharti S, Singh P, Viswanadh MK, Kumari L, Agrawal P, Singh S, Koch B, Muthu MS. Trastuzumab decorated TPGS-g-chitosan nanoparticles for targeted breast cancer therapy. Colloids and Surfaces B: Biointerfaces. 2019;173:366-77.

6.      Singh C, Mehata AK, Viswanadh MK, Tiwari P, Saini R, Singh SK, Tilak R, Tiwari KN, Muthu MS. Chitosan film of thiolated TPGS-modified Au-Ag nanoparticles for combating multidrug-resistant bacteria. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2024;686:133287.

7.      Vikas, Mehata AK, Viswanadh MK, Malik AK, Setia A, Kumari P, Mahto SK, Muthu MS. EGFR targeted redox sensitive chitosan nanoparticles of cabazitaxel: dual-targeted cancer therapy, lung distribution, and targeting studies by photoacoustic and optical imaging. ACS Biomacromolecules. 2023;24(11):4989-5003.

8.      Narendra, Mehata AK, Viswanadh MK, Sonkar R, Pawde DM, Priya V, Singh M, Koch B, S Muthu M. Formulation and in vitro evaluation of upconversion nanoparticle-loaded liposomes for brain cancer. Therapeutic Delivery. 2020;11(9):557-71.

9.      Badgujar P, Malik AK, Mehata AK, Setia A, Verma N, Randhave N, Shukla VN, Kande V, Singh P, Tiwari P, Mahto SK. Polyvinyl alcohol-chitosan loaded oleanolic acid nanofibers against bacterial infection: In vitro studies and in-vivo evaluation by optical and laser Doppler imaging modalities. International Journal of Biological Macromolecules. 2024:135532.

10.  Verma N, Setia A, Mehata AK, Randhave N, Badgujar P, Malik AK, Muthu MS. Recent Advancement of Indocyanine Green Based Nanotheranostics for Imaging and Therapy of Coronary Atherosclerosis. Molecular Pharmaceutics. 2024 Sep 9.

11.  Vikas, Viswanadh MK, Mehata AK, Sharma V, Priya V, Varshney N, Mahto SK, Muthu MS. Bioadhesive chitosan nanoparticles: Dual targeting and pharmacokinetic aspects for advanced lung cancer treatment. Carbohydrate Polymers. 2021;274:118617.

12.  Suseela MN, Mehata AK, Vallamkonda B, Gokul P, Pradhan A, Pandey J, Selvin J, Hudson MS, Muthu MS. Comparative evaluation of liquid-liquid extraction and nanosorbent extraction for HPLC-PDA analysis of cabazitaxel from rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2024;245:116149.

13.  Chauhan M, Shekhar S, Yadav B, Garg V, Dutt R, Mehata AK, Goswami P, Koch B, Muthu MS, Singh RP. AS1411 aptamer/RGD dual functionalized theranostic chitosan-PLGA nanoparticles for brain cancer treatment and imaging. Biomaterials Advances. 2024:213833.

14.  Sonker P, Tamang R, Mehata AK, Nidhar M, Sharma VP, Kumar V, Muthu MS, Koch B, Tewari AK. PTSA-induced synthesis, in silico and nano study of novel ethylquinolin–thiazolo–triazole in cervical cancer. Future Medicinal Chemistry. 2024.

15.  Malik, AK., Singh, C, Tiwari, P, Verma, D, Mehata, AK, Setia, A, Mukherjee, A and Muthu, MS, 2024. Nanofibers of N, N, N-trimethyl chitosan capped bimetallic nanoparticles: Preparation, characterization, wound dressing and in-vivo treatment of MDR microbial infection and tracking by optical and photoacoustic imaging. International Journal of Biological Macromolecules, 2024.130154.

16.  Setia A, Kumari P, Mehata AK, Malik AK, Mahto SK, Muthu MS. Cetuximab decorated redox sensitive D-alpha-tocopheryl-polyethyleneglycol-1000-succinate based nanoparticles for cabazitaxel delivery: Formulation, lung targeting and enhanced anti-cancer effects. International Journal of Pharmaceutics. 2024:123881.

17.  Shukla VN, Mehata AK, Setia A, Kumari P, Mahto SK, Muthu MS, Mishra SK. Rational design of surface engineered albumin nanoparticles of asiatic acid for EGFR targeted delivery to lung cancer: Formulation development and pharmacokinetics. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023;676:132188.

18.  Chauhan M, Singh RP, Yadav B, Shekhar S, Kumar L, Mehata AK, Jhawat V, Dutt R, Garg V, Kailashiya V, Muthu MS. Dual-targeted transferrin and AS1411 aptamer conjugated micelles for improved therapeutic efficacy and imaging of brain cancer. Colloids and Surfaces B: Biointerfaces. 2023 1;231:113544.

19.  Chauhan M, Singh RP, Yadav B, Shekhar S, Kumar A, Mehata AK, Nayak AK, Dutt R, Garg V, Kailashiya V, Muthu MS. Development and characterization of micelles for nucleolin-targeted co-delivery of docetaxel and upconversion nanoparticles for theranostic applications in brain cancer therapy. Journal of Drug Delivery Science and Technology. 2023;87:104808.

20.  Shukla VN, Mehata AK, Setia A, Kumari P, Mahto SK, Muthu MS, Mishra SK. EGFR targeted albumin nanoparticles of oleanolic acid: In silico screening of nanocarrier, cytotoxicity and pharmacokinetics for lung cancer therapy. International Journal of Biological Macromolecules. 2023;246:125719.

21.  Singh C, Mehata AK, Tiwari P, Setia A, Malik AK, Singh SK, Tilak R, Muthu MS. Design of novel bioadhesive chitosan film loaded with bimetallic gold-silver nanoparticles for antibiofilm and wound healing activity. Biomedical Materials. 2023;18(2):025014.

22.  Yadav B, Chauhan M, Shekhar S, Kumar A, Mehata AK, Nayak AK, Dutt R, Garg V, Kailashiya V, Muthu MS, Singh RP. RGD-decorated PLGA nanoparticles improved effectiveness and safety of cisplatin for lung cancer therapy. International Journal of Pharmaceutics. 2023;633:122587.

23.  Priya V, Singh SK, Revand R, Kumar S, Mehata AK, Sushmitha P, Mahto SK, Muthu MS. GPIIb/IIIa receptor targeted rutin loaded liposomes for site-specific antithrombotic effect. Molecular Pharmaceutics. 2022;20(1):663-79.

24.  Rout SK, Priya V, Mehata AK, Muthu MS. Abciximab coated albumin nanoparticles of rutin for improved and targeted antithrombotic effect. Journal of Drug Delivery Science and Technology. 2022;76:103785.

25.  Priya V, Mehata AK, Jain D, Singh SK, Muthu MS. Efficient delivery of abciximab using mesoporous silica nanoparticles: In-vitro assessment for targeted and improved antithrombotic activity. Colloids and Surfaces B: Biointerfaces. 2022;218:112697.

26.  Dehari D, Mehata AK, Priya V, Parbat D, Kumar D, Srivastava AK, Singh S, Agrawal AK. Luliconazole nail lacquer for the treatment of onychomycosis: formulation, characterization and in vitro and ex vivo evaluation. AAPS PharmSciTech. 2022;23(6):175.

27.  Viswanadh MK, Vikas, Jha A, Reddy Adena SK, Mehata AK, Priya V, Neogi K, Poddar S, Mahto SK, Muthu MS. Formulation and in vivo efficacy study of cetuximab decorated targeted bioadhesive nanomedicine for non-small-cell lung cancer therapy. Nanomedicine. 2020;15(24):2345-67.

28.  Jha A, Viswanadh MK, Burande AS, Mehata AK, Poddar S, Yadav K, Mahto SK, Parmar AS, Muthu MS. DNA biodots based targeted theranostic nanomedicine for the imaging and treatment of non-small cell lung cancer. International journal of biological macromolecules. 2020;150:413-25.

29.  Pawde DM, Viswanadh MK, Mehata AK, Sonkar R, Poddar S, Burande AS, Jha A, Vajanthri KY, Mahto SK, Dustakeer VA, Muthu MS. Mannose receptor targeted bioadhesive chitosan nanoparticles of clofazimine for effective therapy of tuberculosis. Saudi Pharmaceutical Journal. 2020;28(12):1616-25.

30.  Vikas, Viswanadh MK, Priya V, Mehata AK, Muthu MS. What are the unexplored facts about nanomicelles formed from docetaxel clinical injection?. Therapeutic Delivery. 2020;11(1):801-3.

31.  Agrawal P, Singh RP, Kumari L, Sharma G, Koch B, Rajesh CV, Mehata AK, Singh S, Pandey BL, Muthu MS. TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy. Materials science and engineering: C. 2017;74:167-76.

32.  Agrawal P, Singh RP, Sharma G, Mehata AK, Singh S, Rajesh CV, Pandey BL, Koch B, Muthu MS. Bioadhesive micelles of d-α-tocopherol polyethylene glycol succinate 1000: Synergism of chitosan and transferrin in targeted drug delivery. Colloids and Surfaces B: Biointerfaces. 2017;152:277-88.

Review

33.  Singh C, Mehata AK, Muthu MS, Tiwari KN. Premna integrifolia: A Review on the Exploration of its Potential Pharmacological and Therapeutic Properties. Current Traditional Medicine. 2024;10(2):37-50.

34.  Malik AK, Setia A, Mehata AK, Priya V, Nikitha Lakshmi Suseela M, Gokul P, Jac Fredo AR, Jain SK, Selvin J, Muthu MS. Green analytical chemistry: Experimental and chemometric methods for the detection of therapeutics using liquid chromatography in wastewater samples. Analytical Chemistry Letters. 2024:1-28.

35.  Setia A, Vallamkonda B, Challa RR, Mehata AK, Badgujar P, Muthu MS. Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules. Nanotheranostics. 2024;8(3):344.

36.  Randhave N, Setia A, Challa RR, Vallamkonda B, Badgujar P, Verma N, Malik AK, Mehata AK, Muthu MS. Autophagy Targeted Nanomedicines and Nanotheranostics In Cancer Imaging and Therapy. Journal of Drug Delivery Science and Technology. 2024:105945.

37.  Setia A, Mehata AK, Priya V, Pradhan A, Prasanna P, Mohan S, Muthu MS. Nanoparticles for Thrombus Diagnosis and Therapy: Emerging Trends in Thrombus-theranostics. Nanotheranostics. 2024;8(2):127.

38.  Dhamija P, Mehata AK, Setia A, Priya V, Malik AK, Bonlawar J, Verma N, Badgujar P, Randhave N, Muthu MS. Nanotheranostics: molecular diagnostics and nanotherapeutic evaluation by photoacoustic/ultrasound imaging in small animals. Molecular Pharmaceutics. 2023;20(12):6010-34.

39.  Setia A, Mehata AK, Priya V, Pawde DM, Jain D, Mahto SK, Muthu MS. Current advances in nanotheranostics for molecular imaging and therapy of cardiovascular disorders. Molecular Pharmaceutics. 2023 Sep 12;20(10):4922-41.

40.  Suseela MN, Viswanadh MK, Mehata AK, Priya V, Setia A, Malik AK, Gokul P, Selvin J, Muthu MS. Advances in solid-phase extraction techniques: Role of nanosorbents for the enrichment of antibiotics for analytical quantification. Journal of Chromatography A. 2023;1695:463937.

41.  Mehata AK, Vikas, Viswanadh MK, Muthu MS. Theranostics of metal–organic frameworks: image-guided nanomedicine for clinical translation. Nanomedicine. 2023;18(8):695-703.

42.  Mehata AK, Gupta N, Muthu MS. Exosomes as a novel nanomedicine platform for personalized triple-negative breast cancer therapy. Nanomedicine. 2023 ;18(6):501-4.

43.  Setia A, Mehata AK, Malik AK, Viswanadh MK, Muthu MS. Theranostic magnetic nanoparticles: Synthesis, properties, toxicity, and emerging trends for biomedical applications. Journal of Drug Delivery Science and Technology. 2023;81:104295.

44.  Singh C, Mehata AK, Priya V, Malik AK, Setia A, Suseela MN, Vikas, Gokul P, Samridhi, Singh SK, Muthu MS. Bimetallic Au–Ag nanoparticles: advanced nanotechnology for tackling antimicrobial resistance. Molecules. 2022;27(20):7059.

45.  Rout SK, Priya V, Setia A, Mehata AK, Mohan S, Albratty M, Najmi A, Meraya AM, Makeen HA, Tambuwala MM, Muthu MS. Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy. Biomedicine & Pharmacotherapy. 2022;153:113451.

46.  Vikas, Sahu HK, Mehata AK, Viswanadh MK, Priya V, Muthu MS. Dual-receptor-targeted nanomedicines: emerging trends and advances in lung cancer therapeutics. Nanomedicine. 2022 17(19):1375-95.

47.  Mehata AK, Suseela MN, Gokul P, Malik AK, Viswanadh MK, Singh C, Selvin J, Muthu MS. Fast and highly efficient liquid chromatographic methods for qualification and quantification of antibiotic residues from environmental waste. Microchemical Journal. 2022;179:107573.

48.  Manners N, Priya V, Mehata AK, Rawat M, Mohan S, Makeen HA, Albratty M, Albarrati A, Meraya AM, Muthu MS. Theranostic nanomedicines for the treatment of cardiovascular and related diseases: current strategies and future perspectives. Pharmaceuticals. 2022;15(4):441.

49.  Mehata AK, Viswanadh MK, Priya V, Vikas, Muthu MS. Harnessing immunological targets for COVID-19 immunotherapy. Future Virology. 2021 Sep;16(9):619-40.

50.  Priya V, Viswanadh MK, Mehata AK, Jain D, Singh SK, Muthu MS. Targeted nanotherapeutics in the prophylaxis and treatment of thrombosis. Nanomedicine. 2021;16(13):1153-76.

51.  Mehata AK, Dehari D, Gupta A, Rabin DC, Miya A. Multifunctional liquid crystal nanoparticles for cancer therapy. Current Nanomaterials. 2021;6(1):4-16.

52.  Mehata AK, Dehari D, Mehta AK, Miya A. Boosting Innate Immunity During SARS-CoV-2 Clearance. Coronaviruses. 2021;2(8):2-3.

53.  Mehata AK, Viswanadh MK, Priya V, Vikas, Muthu MS. Dendritic cell-targeted theranostic nanomedicine: advanced cancer nanotechnology for diagnosis and therapy. Nanomedicine. 2020;15(10):947-9.

54.  Mehata AK, Dehari D. Bradford assay as a high-throughput bioanalytical screening method for conforming pathophysiological state of the animal. Journal of Drug Delivery and Therapeutics. 2020;10(1-s):105-10.

55.  Mehata AK, Dehari D, Ayyannan SR, Muthu MS. X-ray powder diffraction spectroscopy as a robust tool in early predicting bioavailability of pharmaceutical formulation containing polymorphic drug substance. Drug Delivery Letters. 2020;10(3):250-4.

56.  Sonali, Viswanadh MK, Singh RP, Agrawal P, Mehata AK, Pawde DM, Sonkar R, Muthu MS. Nanotheranostics: emerging strategies for early diagnosis and therapy of brain cancer. Nanotheranostics. 2018;2(1):70.

57.  Muthu MS, Mehata AK, Viswanadh MK. Upconversion nanotheranostics: emerging designs for integration of diagnosis and therapy. Nanomedicine. 2017;12(6):577-80.

58.  Kaklotar D, Agrawal P, Abdulla A, Singh RP, Mehata AK, Singh S, Mishra B, Pandey BL, Trigunayat A, Muthu MS. Transition from passive to active targeting of oral insulin nanomedicines: enhancement in bioavailability and glycemic control in diabetes. Nanomedicine. 2016;11(11):1465-86.

Book chapters

59.  Vikas, Mehata AK, Singh C, Malik AK, Setia A, Muthu MS. Alginate-Based Hydrogels as Drug Carriers. InBiomaterial-based Hydrogels: Therapeutics Carrier and Tissue Regeneration 2024 Apr 13 (pp. 39-65). Singapore: Springer Nature Singapore.

60.  Setia A, Mehata AK, Priya V, Malik AK, Muthu MS. Synthesis and processing methods of magnetic nanosystems for diagnostic tools and devices: Design strategies and physicochemical aspects. InFunctionalized Magnetic Nanosystems for Diagnostic Tools and Devices 2024 Jan 1 (pp. 43-78). Elsevier.

61.  Mehata AK, Viswanadh MK, Prasanna P, Kumar M, Muthu MS. Theranostic Applications of Upconversion Nanoparticle-Based Drug-Delivery Systems. InNanomaterial-Based Drug Delivery Systems: Therapeutic and Theranostic Applications 2023 Jun 22 (pp. 239-268). Cham: Springer International Publishing.

62.  Vikas, Mehata AK, Singh C, Malik AK, Setia A, Muthu MS. Alginate in Cancer Therapy. InAlginate Biomaterial: Drug Delivery Strategies and Biomedical Engineering 2023 Feb 1 (pp. 267-295). Singapore: Springer Nature Singapore.

63.  Mehata AK, Muthu MS. Development of Supramolecules in the Field of Nanomedicines. InPharmaceutical Applications of Supramolecules 2023 Jan 16 (pp. 211-239). Cham: Springer International Publishing.

64.  Mehata AK, Dehari D, Priya V, Muthu MS. Drug-releasing textile materials: Current developments and future perspectives. InFiber and Textile Engineering in Drug Delivery Systems 2023 Jan 1 (pp. 1-38). Woodhead Publishing.

65.  Mehata AK, Viswanadh MK, Solomon VR, Muthu MS. Radionanotheranostics for breast cancer diagnosis and therapy: Recent advances and future opportunities. Targeted Nanomedicine for Breast Cancer Therapy. 2022 Jan 1:465-508.

Patents filed

1. A polymeric nano-formulation and a method of preparation thereof (202411054569).

2. Copper (Cu(II)) complex and method of preparation thereof  (202441082868).

3. An anti-cancerous nanocomposition and a method of preparation thereof (202511008621) 

4. A ruthenium-based thione complex having anticancer activity and a method of preparation thereof (202541021105 ).

5. Ferrocene-coumarin complex and method of preparation thereof (202541021928).